ABSTRACT
Objective:To investigate the effects of Danhong injection combined with intravenous recombinant tissue plasminogen activator (rt-PA) on cardiac function, myocardial zymogram and lipoprotein associated phospholipase A2 (Lp-PLA2) level in older adult patients with acute myocardial infarction (AMI). Methods:Eighty older adult patients with acute myocardial infarction who received treatment in Community-based General Hospital of Shaoxing Central Hospital, China between January 2017 and December 2019 were included in this study. They were randomly assigned to receive either intravenous thrombolysis with rt-PA (control group, n = 40) or Danhong injection combined with intravenous thrombolysis with rt-PA (observation group, n = 40). The changes in traditional Chinese medicine syndrome score, left ventricular ejection fraction, left ventricular end diastolic diameter, creatine kinase, creatine kinase-MB and lipoprotein associated phospholipase A2 level as well as adverse cardiovascular events were compared between the control and observation groups. Results:After treatment, the score of chest tightness, dark purple tongue, palpitation and shortness of breath in the two groups were decreased. After treatment, the score of chest tightness, dark purple tongue, palpitation and shortness of breath in the observation group was (2.13 ± 0.31) points, (1.98 ± 0.41) points, (1.77 ± 0.29) points, respectively, which was significantly lower than that in the control group [(2.98 ± 0.37) points, (2.52 ± 0.56) points, (2.13 ± 0.32) points, t = 11.137, 4.920, 5.272, all P < 0.001]. After treatment, left ventricular end diastolic diameter in each group was decreased compared with before treatment. After treatment, left ventricular end diastolic diameter in the observation group was significantly lower than that in the control group [(46.12 ± 4.11) mm vs. (49.74 ± 4.32) mm], and left ventricular ejection fraction in the observation group was significantly higher than that in the control group [(47.02 ± 3.55) % vs. (43.25 ± 4.10) %, t = 3.839, 4.396, both P < 0.001). After treatment, Lp-PLA2, creatine kinase, creatine kinase-MB levels in each group were decreased compared with before treatment. After treatment, Lp-PLA2, creatine kinase, creatine kinase-MB levels in the observation group were (171.02 ± 12.52) μg /L, (10.52 ± 2.11) U/L, (24.12 ± 3.52) U/L), respectively, which were significantly lower than those in the control group [(189.63 ± 11.98) μg/L, (14.71 ± 2.62) U/L, (32.79 ± 4.79) U/L), t = 6.792, 7.877, 9.224, all P < 0.001]. The incidence of adverse cardiovascular events in the observation group was significantly lower than that in the control group (5.00% vs. 22.50%, χ2 = 5.165, P < 0.05). Conclusion:Danhong injection combined with intravenous rt-PA for the treatment of acute myocardial infarction in older adult patients can greatly decrease traditional Chinese medicine syndrome score, improve cardiac function, regulate myocardial zymogram and Lp-PLA2 levels, and decrease the incidence of adverse cardiovascular events.
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Objective@#To investigate the effect of cephalosporin sequential therapy on acute mesenteric lymphadenitis caused by bacterial infection.@*Methods@#From December 2015 to December 2018, 66 patients with acute mesenteric lymphadenitis caused by bacterial infection in Shaoxing Central Hospital were randomly selected.The control group(33 cases) received intravenous infusion of cefuroxime.The observation group(33 cases) was treated with intravenous infusion of cefuroxime, after the abdominal pain disappeared and the peripheral blood cell count returned to normal, the cefuroxime axetil tablet was given orally.The clinical efficacy of the two groups was evaluated, and the treatment costs and adverse reactions of the two groups were counted.@*Results@#The total effective rate of the observation group was 96.97%(32/33), compared with 90.91%(30/33) of the control group, the difference was not statistically significant(χ2=1.26, P=0.53). The total cost of treatment in the observation group was (326.85±51.88)CNY, which was lower than that of the control group[(576.82±72.17)CNY], the difference was statistically significant(t=16.15, P=0.00). There were no significant adverse reactions in the two groups during treatment periods.@*Conclusion@#Sequential therapy with cefuroxime and venous infusion of cefuroxime for the treatment of acute mesenteric lymphadenitis in children with bacterial infection is safe, but sequential therapy is less expensive and therefore recommended.
ABSTRACT
To investigate the effect of cephalosporin sequential therapy on acute mesenteric lymphadenitis caused by bacterial infection.Methods From December 2015 to December 2018,66 patients with acute mesenteric lymphadenitis caused by bacterial infection in Shaoxing Central Hospital were randomly selected .The control group(33 cases) received intravenous infusion of cefuroxime.The observation group (33 cases) was treated with intravenous infusion of cefuroxime ,after the abdominal pain disappeared and the peripheral blood cell count returned to normal,the cefuroxime axetil tablet was given orally.The clinical efficacy of the two groups was evaluated , and the treatment costs and adverse reactions of the two groups were counted .Results The total effective rate of the observation group was 96.97%(32／33),compared with 90.91%(30／33) of the control group,the difference was not statistically significant(χ2 ＝1.26,P＝0.53).The total cost of treatment in the observation group was (326.85 ± 51.88)CNY,which was lower than that of the control group [(576.82 ±72.17)CNY],the difference was statistically significant(t＝16.15,P ＝0.00).There were no significant adverse reactions in the two groups during treatment periods.Conclusion Sequential therapy with cefuroxime and venous infusion of cefuroxime for the treatment of acute mesenteric lymphadenitis in children with bacterial infection is safe , but sequential therapy is less expensive and therefore recommended.
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Objective To explore the effect of comprehensive interventions on protective behaviors of sanitary workers against occupational exposure in hospitals. Methods Comprehensive interventions were done in 50 sanitary workers in our hospital during September 2013 to September 2014, with the intervention contents including establishment of sanitary workers management system, education training, on-the-spot inspection, signature of duty informs, planning of occupational exposure prevention flow chart. The intervention lasted 12 months. Then the score on occupational exposure prevention knowledge and behaviors, the qualification rate of all indexes and all occupational harms in pre-intervention and post-intervention were compared. Result The score on occupational exposure preventive knowledge after intervention was significantly higher than that before intervention , the qualification rate after intervention was higher than that before intervention and the incurrence of occupational harms was significantly lower than that before intervention (P < 0.01). Conclusion Multiple measures including education, supervision, inspection, duty informing and flow chats can strengthen the awareness of preventing occupational exposure and lower the incidence of occupational harms among the sanitary workers.